diff --git a/docs/content/storage-drivers/s3.md b/docs/content/storage-drivers/s3.md
index 03c04a6dd..f50cc3d20 100644
--- a/docs/content/storage-drivers/s3.md
+++ b/docs/content/storage-drivers/s3.md
@@ -77,6 +77,9 @@ Amazon S3 or S3 compatible services for object storage.
 
 `loglevel`: (optional) Valid values are: `off` (default), `debug`, `debugwithsigning`, `debugwithhttpbody`, `debugwithrequestretries`, `debugwithrequesterrors` and `debugwitheventstreambody`. See the [AWS SDK for Go API reference](https://docs.aws.amazon.com/sdk-for-go/api/aws/#LogLevelType) for details.
 
+**NOTE:** Currently the S3 storage driver only supports S3 API compatible storage that
+allows parts of a multipart upload to vary in size. [Cloudflare R2 is not supported.](https://developers.cloudflare.com/r2/objects/multipart-objects/#limitations)
+
 ## S3 permission scopes
 
 The following AWS policy is required by the registry for push and pull. Make sure to replace `S3_BUCKET_NAME` with the name of your bucket.
diff --git a/registry/storage/driver/s3-aws/s3.go b/registry/storage/driver/s3-aws/s3.go
index 2d51ddf7f..60e205dbc 100644
--- a/registry/storage/driver/s3-aws/s3.go
+++ b/registry/storage/driver/s3-aws/s3.go
@@ -111,7 +111,6 @@ type DriverParameters struct {
 	MultipartCopyChunkSize      int64
 	MultipartCopyMaxConcurrency int64
 	MultipartCopyThresholdSize  int64
-	MultipartCombineSmallPart   bool
 	RootDirectory               string
 	StorageClass                string
 	UserAgent                   string
@@ -165,7 +164,6 @@ type driver struct {
 	MultipartCopyChunkSize      int64
 	MultipartCopyMaxConcurrency int64
 	MultipartCopyThresholdSize  int64
-	MultipartCombineSmallPart   bool
 	RootDirectory               string
 	StorageClass                string
 	ObjectACL                   string
@@ -405,23 +403,6 @@ func FromParameters(ctx context.Context, parameters map[string]interface{}) (*Dr
 		return nil, fmt.Errorf("the useDualStack parameter should be a boolean")
 	}
 
-	mutlipartCombineSmallPart := true
-	combine := parameters["multipartcombinesmallpart"]
-	switch combine := combine.(type) {
-	case string:
-		b, err := strconv.ParseBool(combine)
-		if err != nil {
-			return nil, fmt.Errorf("the multipartcombinesmallpart parameter should be a boolean")
-		}
-		mutlipartCombineSmallPart = b
-	case bool:
-		mutlipartCombineSmallPart = combine
-	case nil:
-		// do nothing
-	default:
-		return nil, fmt.Errorf("the multipartcombinesmallpart parameter should be a boolean")
-	}
-
 	sessionToken := ""
 
 	accelerateBool := false
@@ -457,7 +438,6 @@ func FromParameters(ctx context.Context, parameters map[string]interface{}) (*Dr
 		multipartCopyChunkSize,
 		multipartCopyMaxConcurrency,
 		multipartCopyThresholdSize,
-		mutlipartCombineSmallPart,
 		fmt.Sprint(rootDirectory),
 		storageClass,
 		fmt.Sprint(userAgent),
@@ -607,7 +587,6 @@ func New(ctx context.Context, params DriverParameters) (*Driver, error) {
 		MultipartCopyChunkSize:      params.MultipartCopyChunkSize,
 		MultipartCopyMaxConcurrency: params.MultipartCopyMaxConcurrency,
 		MultipartCopyThresholdSize:  params.MultipartCopyThresholdSize,
-		MultipartCombineSmallPart:   params.MultipartCombineSmallPart,
 		RootDirectory:               params.RootDirectory,
 		StorageClass:                params.StorageClass,
 		ObjectACL:                   params.ObjectACL,
@@ -1635,7 +1614,7 @@ func (w *writer) flush() error {
 	}
 
 	buf := bytes.NewBuffer(w.ready.data)
-	if w.driver.MultipartCombineSmallPart && (w.pending.Len() > 0 && w.pending.Len() < int(w.driver.ChunkSize)) {
+	if w.pending.Len() > 0 && w.pending.Len() < int(w.driver.ChunkSize) {
 		if _, err := buf.Write(w.pending.data); err != nil {
 			return err
 		}
diff --git a/registry/storage/driver/s3-aws/s3_test.go b/registry/storage/driver/s3-aws/s3_test.go
index 3d334854b..d79898011 100644
--- a/registry/storage/driver/s3-aws/s3_test.go
+++ b/registry/storage/driver/s3-aws/s3_test.go
@@ -29,23 +29,22 @@ var (
 
 func init() {
 	var (
-		accessKey        = os.Getenv("AWS_ACCESS_KEY")
-		secretKey        = os.Getenv("AWS_SECRET_KEY")
-		bucket           = os.Getenv("S3_BUCKET")
-		encrypt          = os.Getenv("S3_ENCRYPT")
-		keyID            = os.Getenv("S3_KEY_ID")
-		secure           = os.Getenv("S3_SECURE")
-		skipVerify       = os.Getenv("S3_SKIP_VERIFY")
-		v4Auth           = os.Getenv("S3_V4_AUTH")
-		region           = os.Getenv("AWS_REGION")
-		objectACL        = os.Getenv("S3_OBJECT_ACL")
-		regionEndpoint   = os.Getenv("REGION_ENDPOINT")
-		forcePathStyle   = os.Getenv("AWS_S3_FORCE_PATH_STYLE")
-		sessionToken     = os.Getenv("AWS_SESSION_TOKEN")
-		useDualStack     = os.Getenv("S3_USE_DUALSTACK")
-		combineSmallPart = os.Getenv("MULTIPART_COMBINE_SMALL_PART")
-		accelerate       = os.Getenv("S3_ACCELERATE")
-		logLevel         = os.Getenv("S3_LOGLEVEL")
+		accessKey      = os.Getenv("AWS_ACCESS_KEY")
+		secretKey      = os.Getenv("AWS_SECRET_KEY")
+		bucket         = os.Getenv("S3_BUCKET")
+		encrypt        = os.Getenv("S3_ENCRYPT")
+		keyID          = os.Getenv("S3_KEY_ID")
+		secure         = os.Getenv("S3_SECURE")
+		skipVerify     = os.Getenv("S3_SKIP_VERIFY")
+		v4Auth         = os.Getenv("S3_V4_AUTH")
+		region         = os.Getenv("AWS_REGION")
+		objectACL      = os.Getenv("S3_OBJECT_ACL")
+		regionEndpoint = os.Getenv("REGION_ENDPOINT")
+		forcePathStyle = os.Getenv("AWS_S3_FORCE_PATH_STYLE")
+		sessionToken   = os.Getenv("AWS_SESSION_TOKEN")
+		useDualStack   = os.Getenv("S3_USE_DUALSTACK")
+		accelerate     = os.Getenv("S3_ACCELERATE")
+		logLevel       = os.Getenv("S3_LOGLEVEL")
 	)
 
 	var err error
@@ -94,14 +93,6 @@ func init() {
 			useDualStackBool, err = strconv.ParseBool(useDualStack)
 		}
 
-		multipartCombineSmallPart := true
-		if combineSmallPart != "" {
-			multipartCombineSmallPart, err = strconv.ParseBool(combineSmallPart)
-			if err != nil {
-				return nil, err
-			}
-		}
-
 		accelerateBool := true
 		if accelerate != "" {
 			accelerateBool, err = strconv.ParseBool(accelerate)
@@ -126,7 +117,6 @@ func init() {
 			defaultMultipartCopyChunkSize,
 			defaultMultipartCopyMaxConcurrency,
 			defaultMultipartCopyThresholdSize,
-			multipartCombineSmallPart,
 			rootDirectory,
 			storageClass,
 			driverName + "-test",